pharmaceutical businesses world wide. the 1st chapters hint the advance of our figuring out of drug metabolite toxicity, protecting easy thoughts and methods within the strategy, whereas the second one half information chemical toxicophores which are at risk of reactive metabolite formation. This part additionally studies a number of the drug-metabolizing enzymes which could perform catalyzing reactive metabolite formation, together with a dialogue of the structure-toxicity relationships for medicines. chapters are devoted to the presently scorching themes of natural parts and IADRs.
the following half covers present ideas and techniques to guage the reactive metabolite power of latest drug applicants, either through predictive
and through bioanalytical tools. There then follows an in-depth research of the toxicological capability of the pinnacle two hundred prescribed drugs, illustrating
the ability and the bounds of the toxicophore idea, sponsored by means of various case reports. ultimately, a risk-benefi t method of handling the toxicity chance of reactive metabolite-prone medicinal drugs is presented.
because the authors conscientiously increase the data wanted, from basic issues to present criteria, no measure in pharmacology is needed to learn this publication, making it ideal for medicinal chemists with out in-depth pharmacology training.
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Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry)